However, after 50 days of therapy, the effects were not as significant; therefore, C. molmol may be of interest as an anticarcinogenic agent for solid tumors.26, In another study of mice, C. molmol doses of 125 to 500 mg/kg were not mutagenic. Today, demand for frankincense and myrrh has subsided, but numerous Chinese, Greek, Latin and Sanskrit sources remind us of their past importance. Dolara P, Corte B, Ghelardini C, et al. Multiple times, Myrrh has been mentioned in the Bible as it was one of the gifts given by the tree wise men who visited Jesus.The other gifts included Gold, which symbolizes kingship, and Frankincense, which symbolizes worship. Myrrh oil is very famous for its soothing properties, anti-depressant and uplifting spirit. Al-Jaroudi D, Kaddour O, Al-Amin N. Risks of myrrh use in pregnancy. At this time there is not enough scientific information to determine an appropriate range of doses for myrrh. This information is not specific medical advice and does not replace information you receive from your health care provider. Chemotherapy 1994:40:337-47. No adverse reactions were reported.14, An in vitro study of 2 sesquiterpenes derived from myrrh (furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one) discovered antibacterial activity against Pseudomonas aeruginosa (minimum inhibitory concentration [MIC] 1.4 mcg/mL), Staphylococcus aureus (MIC 0.18 mcg/mL), and Escherichia coli (MIC 2.8 mcg/mL). Although several preliminary studies indicate that myrrh essential oil may offer certain health benefits, there is currently a lack of research testing the health effects of aromatherapeutic use of myrrh essential oil. Myrrh in the Bible Myrrh frequently appears in the Old Testament, primarily as a sensuous perfume in the Song of Solomon : An in vitro study of the anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells was conducted. Neither myrrh nor Mirazid reduced hepatic or intestinal tissue egg loads, whereas praziquantel reduced these levels by 60% and 90%, respectively. It has also been used as an astringent, as an antiseptic to be applied to inflamed lesions of the throat and mouth, and as an emmenagogue and an antispasmodic, and for the treatment of cancer and infectious diseases. Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis-a double-blind, double-dummy study. But taking myrrh alone doesn't work as well as taking myrrh along with the drug. This product may be unsafe when used before surgery or other medical procedures. Of the infected subjects, 104 were randomized to receive either myrrh (2 capsules of Mirazid on an empty stomach for 3 consecutive days) or 2 doses praziquantel (40 mg/kg after breakfast) at a 3-week interval as antischistosomal therapy. Early research shows that taking myrrh along with the drug paromomycin helps treat this infection better than taking the drug alone. The wound was cleaned daily followed by application of the paste. Thought to be effective for pain relief, including menstrual pain resulting from blood stagnation. Sixty male mice were divided into 3 groups: group 1 was the noninfected control group; group 2 contained biharzially infected mice; and group 3 contained biharzially infected mice that were treated with myrrh extract 500 mg/kg for 5 consecutive days 8 weeks after infection. Infection of the intestines by parasites. Myrrh is a sap-like substance (resin) that comes out of cuts in the bark of trees that are members of the Commiphora species. View abstract. After 2 months, patients who still had evidence of ova received another course of myrrh for 6 days. J Ethnopharmacol 2011;134(2):251-8. He was managed with antibiotics, glycemic control, pentoxifylline, vitamin C, calcium carbonate, vitamin E, vitamin A, zinc, and bee propolis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Am J Trop Med Hyg 2005 Feb; 72(2):119-23. All participants were given a formulation of myrrh at a dose of 12 mg/kg/day for 6 consecutive days on an empty stomach in the morning. Myrrh is used for indigestion, ulcers, colds, cough , asthma , lung congestion , arthritis pain , cancer , leprosy , spasms, and syphilis . This information may not fit your specific health circumstances. No clinical studies of myrrh as an antitumor or anticarcinogenic agent in humans have been documented. Danso-Appiah A, Olliaro PL, Donegan S, Sinclair D, Utzinger J. Keep in mind that natural products are not always necessarily safe and dosages can be important. Myrrh is used for problems in the stomach and intestines, congestion, parasite infections, and many other conditions, but there is no good scientific evidence to support these uses. Mirazid alone or combined with paramomycin in treating cryptosporidiosis parvum in immunocompetent hospitalized patients. CONDITIONS OF USE AND IMPORTANT INFORMATION: The children were assessed 4 weeks following treatment, and household contacts were reassessed between 5 and 6 weeks following treatment. Efficacy of mirazid in comparison with praziquantel in Egyptian Schistosoma mansoni-inefcted school children and households. The authors of this study suggest that Mirazid is safe and effective for the treatment of S. haematobium and S. mansoni infections.18, In another study, 21 children with fascioliasis (mean age, 10 years) and 8 children with S. mansoni (mean age, 11 years) received 10 mg/kg/day of myrrh (Mirazid) 1 hour before breakfast for 6 consecutive days (fascioliasis) or 3 consecutive days (schistosomiasis). Chen Y, Zhou C, Ge Z, et al. Evid Based Complement Alternat Med 2015;2015:925432. Infection of the liver by a parasitic worm (fasciolosis). The appropriate dose of myrrh depends on several factors such as the user's age, health, and several other conditions. These tears are approximately the size of a walnut and form the basis of myrrh resin. Myrrh is used to make medicine. As a result, the worms are shifted to the liver where they undergo phagocytosis.13 Additionally, myrrh has been used to treat fascioliasis, a zoonotic condition resulting from infection by Fasciola hepatica, a liver fluke that commonly infects sheep, goats, and cattle.14, The effect of an oleo-resin extract of myrrh in the form of a gelatinous capsule (Mirazid) on the ultrastructure of mice liver was assessed. A pale yellow-white viscous liquid exudes from natural cracks or fissures in the bark or from fissures cut intentionally to harvest the material.3 When air-dried, this exudate hardens into a reddish-brown mass that often contains white patches. Myrrh oil inhibited the production of prostaglandin E2 via interleukin-1β stimulation by the fibroblasts (P = 0.001) but not by the epithelial cells.28 Further studies of myrrh's effects for gingival conditions are warranted. Taking myrrh does not cure this infection in most children and adults. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. The scent is said to boost the spirits and the soul, and is often used to alleviate the symptoms of nervous system disorders. al-Harbi MM, Qureshi S, Raza M, et al. The study included 7 patients between 10 and 41 years of age with confirmed fascioliasis as well as 10 healthy subjects. The observed cure rate may be considered to be false because of a reported cure rate of 27% in the control group, although the patients reported that they had not received any antischistosomal drugs. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Early research shows that taking myrrh for 6-8 days may help cure this infection in women who are not cured after taking the drugs metronidazole and tinidazole. Massoud AM, Shalaby HA, El Khateeb RM, et al. Commiphora mukul, a related species, is not a source of myrrh. The ameliorating effect of myrrh on scopolamine-induced memory impairments in mice. Hibiscus extract, vegetable proteases and Commiphora myrrha are useful to prevent symptomatic UTI episode in patients affected by recurrent uncomplicated urinary tract infections. Careful monitoring of blood glucose is warranted.9, 25, Although myrrh is generally considered to be nonirritating, nonsensitizing, and nonphototoxic to human and animal skin2 several cases of dermatitis caused by myrrh have been reported.32 In case reports of 2 patients using transdermal myrrh formulations for tendonitis, both developed contact dermatitis at the application sites within a few weeks of administration. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Iran Red Crescent Med J 2011;13(7):480-6. Local anesthetic activity was also noted in mammalian nerve cells.11, In a case report, a 65-year-old man with diabetes had a wound on his right foot with tissue loss. View abstract. For instance, both are commonly used in traditional Chinese medicine, Ayurveda and aromatherapy. Twenty healthy subjects were also followed as controls. Everything from the bark of the tree to the sap inside is fragrant, so both frankincense and myrrh are used as incense and perfume. View abstract. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? Trichomoniasis is a sexually transmitted disease caused by a parasite. Eggs had completely disappeared within 3 weeks following treatment and remained eradicated up to the 3-month follow-up. Overall relapse rates were 53% and 45% in the herbal group versus the mesalazine group, respectively, and no significant differences were found between the 2 groups in Colitis Activity Index scores. This study suggested that myrrh extract may have a role as an antischistosomal agent.15, In a multicenter investigation, mice and hamsters were infected with various strains of S. mansoni. Engl., Commiphora molmol Engl., Commiphora myrrha (T. Nees) Engl.Common Name(s): African myrrh, Arabian and Yemen myrrh, Bal, Bol, Bola, Gum myrrh, Heerabol, Myrrha, Myrrhe, Somali Myrrh. The French and British continue to use myrrh in mixtures for the treatment of cough and in suppository form to treat proctitis.4, Myrrh is an oleo-gum-resin obtained from the stem of C. molmol3, 4 that consists of 2% to 10% of a volatile oil composed predominantly of sesquiterpenes, sterols, and steroids. Schistosomiasis is a disease caused by parasitic worms. They are native to Africa, eastern Mediterranean countries, and South Arabia. Where did you or where do you plan to purchase this product? Myrrh has long been used in parts of Asia as a traditional medicine for inflammatory diseases. The livers of group 2 were noted to have alterations in the ultrastructural profile, with the presence of granulomas and intercellular fibrosis. View abstract. Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats. Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). All rights reserved. 1 to 2 teaspoonfuls of resin per 1 cup of boiling water, steep for 10 to 15 minutes and drink 3 times daily.29, Dental powders contain 10% of the powdered resin.1, 9. It was also suggested that cytokine levels may be evaluated to assess cure.19, Another study in Egypt involved 204 patients ranging from 12 to 68 years of age with schiostomiasis. No studies have been conducted to determine the effects of myrrh on gingivitis in animals. No clinical studies of myrrh in the treatment of diabetes in humans have been documented. 86. This study concluded that the Mirazid formulation of myrrh has demonstrated efficacy as a fasciolicidal and schistosomicidal agent. J Egypt Soc Parasitol 2008 Aug; 38(2):399-418. Typically, coconut, jojoba and olive oil are used as carrier oils. Ineffectiveness of myrrh-derivative Mirazid against schistosomiasis and fascioliasis in humans. Pain. For 12 patients who had never received treatment with praziquantel, the cure rate associated with myrrh was 100%. Tegumental histoligical effects of Mirazid and myrrh volatile oil on adult Fasciola gigantica. Additionally, these sesquiterpenes demonstrated antifungal activity against Candida albicans (MIC 1.4 mcg/mL). Myrrh is used to make medicine. What factors influenced or will influence your purchase? View abstract. Clinical trial of mirazid in treatment of human fascioliasis, Ezbet El-Bakly (Tamyia Center) Al-Fayoum Governorate. A laboratory study published in Letters in Applied Microbiology in 2012 found that a combination of myrrh essential oil and frankincense essential oil may … Langhorst J, Varnhagen I, Schneider SB, et al. The effect of Commiphora molmol (Myrrh) in treatment of trichomoniasis vaginalis infection. The water-soluble gum portion (30% to 60%) contains polysaccharides and proteins as well as ethanol-soluble resins (25% to 40%). Bostros S, Sayed, H, El-Dusoki H, Sabry H, Rabie I, et al. This may be partially explained by more adequate absorption and metabolism in patients with normal hepatic function. In the Western world, myrrh sometimes is included as an ingredient in toothpastes and mouthwashes, thanks to its analgesic properties. Documented harmful effects. After 4 weeks of treatment the wound healed completely. Massoud AM, Hafez AO, Abdel-Gawad AG, El-shasly AM, Morsy TA. A pilot study on bioactive constituents and analgesic effects of MyrLiq, a Commiphora myrrha extract with a high furanodiene content. Myrrh is approved by the FDA for food use and was "given generally recognized as safe" status as a flavoring agent.14. Myrrh has also been used for hemorrhoids, possibly due to its anti-inflammatory properties. Myrrh is used as a fragrance in cosmetics and as a flavoring agent in foods and beverages. The dose of your diabetes medication might need to be changed.Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.